FDA warns of child abuse with MMS bleach

In 2020, FDA employees reported on children who had been harmed by chlorine dioxide bleach, a toxic form of snake oil marketed as a cure-all “Miracle Mineral Solution” (MMS).

MMS bleach has been sold to victims of chronic Lyme and autism quackery, so it is not surprising to see Lyme and autism represented in the report.

As detailed by the Houston Press, a bright college student named Jennifer Hollis had a fake Lyme diagnosis which she tried to treat using MMS bleach. With her depression untreated, she died by suicide.

LymeScience republishes:

Harmful effects of chlorine dioxide exposure

Original PDF

Allison Lardieri , Carmen Cheng, S. Christopher Jones, and Lynda McCulley
FDA, Silver Spring, MD, USA

Dear editor,

Chlorine dioxide (CD) products are often marketed under various names (e.g., Miracle Mineral Solution, 28% sodium chlorite) and touted as a cure-all for autism, malaria, cancer, and most recently, coronavirus disease 2019 (COVID-19). However, there is no published evidence to support these claims.

CD products are a mixture of sodium chlorite and an acidic solution. Concentrated CD is not intended for human consumption, and in this letter, we describe acute toxicity associated with it.

The U.S. Food and Drug Administration (FDA) recently issued a consumer warning for CD products with misleading health claims and reports of adverse effects (gastrointestinal symptoms, dehydration, hypotension) [1,2]. Published case reports also describe CD toxicities including methemoglobinemia, hemolytic anemia, toxic irritant dermatitis and Kikuchi-Fujimoto disease [3–7].

We report an analysis of the American Association of Poison Control Centers (AAPCC) National Poison Data System (NPDS) cases of CD-associated exposure (involving Miracle Mineral Solution) from 55 U.S. Poison Centers between January 1, 2000-March 31, 2020. Narratives for 53 CD exposures were obtained; all cases were followed to a known outcome.

An average of five exposures were reported annually (range 3–9) since 2011. Thirty-three (62.3%) cases were female and the median age was 46 years (range 1.6–88). Seven (13.2%) cases occurred in children ages 19 months–11 years. Twenty-nine (54.7%) exposures cited the reporters’ reasons for use in the narrative, including “cure all/supplement” (5/53, 9.4%), accidental exposure (5/53, 9.4%), and detoxification (4/53, 7.5%). The reason for the remaining exposures (24/53, 45.3%) could not be determined from the provided narrative. (See Table 1).

Ingestion was the most common route (44/53, 83%); others included inhalation, dermal, rectal, and ocular. The most frequently reported related clinical effects were vomiting (26/53, 49.1%), nausea (15/53, 28.3%), abdominal pain (12/53, 22.6%), and diarrhea (11/53, 20.8%); some exposures reported multiple effects.

Table 1. Reasons for use, related clinical effects, chronicity, and time to onset reported with chlorine dioxide exposure cases, reported to U.S. poison centers, from January 1, 2000 to March 31, 2020 (N = 53). 

 n (%)
Reason for use as reported in case narratives* 
 Cure all/supplement5 (9.4)
 Accidental exposure5 (9.4)
 Detoxification4 (7.5)
 Constipation2 (3.8)
 Toothache2 (3.8)
 Autism1 (1.9)
 Candida1 (1.9)
 Cold1 (1.9)
 Facial abscess1 (1.9)
 Herpes1 (1.9)
 Lyme disease1 (1.9)
 Lymphoma1 (1.9)
 Shingles1 (1.9)
 Self-harm1 (1.9)
 Scabies1 (1.9)
 Sinus pain1 (1.9)
 Not documented24 (45.3)
Related clinical effects, reported in ≥2 cases** 
 Vomiting26 (49.1)
 Nausea15 (28.3)
 Abdominal Pain12 (22.6)
 Diarrhea11 (20.8)
 Oral/Throat irritation, Cough/choke9 (17.0)
 Burns 2 − 3 degree, Burns (superficial), Oral Burns (include lips)4 (7.5)
 Ocular – Irritation/pain/red eye/conjunctivitis3 (5.7)
 Diaphoresis2 (3.8)
 Chest pain (include noncardiac)2 (3.8)
 Electrolyte abnormality2 (3.8)
Chronicity as categorized by poison center staff 
 Acute45 (84.9)
 Acute-on-chronic1 (1.9)
 Chronic6 (11.3)
 Unknown1 (1.9)
Time to onset as reported in case narratives 
 Immediate to ≤1 hour16 (30.2)
 >1 hour to ≤24 hours24 (45.2)
 >1 day to ≤1 week5 (9.4)
 2 months1 (1.9)
 Unknown7 (13.2)

* We relied on the reason for use as stated in the report because it provided more specificity in determining purported indication than the structured National Poison Data System code.

** Some cases reported more than one related clinical effect. There were 44 cases with a clinical effect assessed as related to chlorine dioxide.

We note the majority of exposures represent acute toxicity (45/53, 84.9%), as most effects occurred immediately or ≤24 h of exposure (40/53, 75.5%). Thirteen patients (24.5%) were hospitalized. Two critical care unit admissions included significant electrolyte abnormalities, electrocardiogram changes, and altered mental status. Both patients recovered after electrolyte and fluid repletion. We suspect these clinical effects were driven by significant electrolyte loss linked to the gastrointestinal effects of CD. Although the NPDS data do not reflect the same toxicities as reported in the literature, this evaluation augments those by providing further evidence of harm from CD exposure.

This report is subject to limitations common to voluntary reporting systems. NPDS provides an incomplete capture of outcomes, which limits our ability to fully characterize cases and quantitatively measure harm attributed to CD use. Additionally, because poison control centers primarily offer advice following acute exposure, the data rarely include late onset clinical effects or long-term complications. We posit there are likely many more exposures than are described in this report, as we limited our search to CD marketed under Miracle Mineral Solution (MMS) and excluded other sodium chlorite products.

FDA has initiated actions against those who fraudulently market CD to treat or prevent COVID-19 [2]. We urge consumers to avoid CD use and we hope to make health care providers aware of potential clinical sequelae associated with CD administration.

Disclosure statement

No potential conflict of interest was reported by the author(s).

References

[1] FDA Consumer Update . August 12, 2019 [Accessed 2020 Mar 6]. Danger: don’t drink miracle mineral solution or similar products. Available from https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products.

[2] FDA News Release . April 8, 2020 [Accessed 2020 Apr 10]. Coronavirus (COVID-19) update: FDA warns seller marketing dangerous chlorine dioxide products that claim to treat or prevent COVID-19. Available from https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-warns-seller-marketing-dangerous-chlorine-dioxide-products-claim.

[3] Arnold J , Rushton W. The mineral miracle disaster: accidental poisoning after use of 28% sodium chlorite solution resulting in methemoglobinemia and mild hemolytic anemia. North American Congress of Clinical Toxicology (NACCT) Abstracts 2018. Clin Toxicol. 2018;56( 10):912–1092.

[4] De Asis Alcantara Nicolas F , Mesonero RP , Molera VM , et al. Irritant contact dermatitis from ‘Miracle Mineral Solution’. J Am Acad Dermatol. 2016;74(5):AB92.

[5] Loh JMR , Shafi H. Kikuchi-Fujimoto disease presenting after consumption of ‘Miracle Mineral Solution’ (sodium chlorite). BMJ Case Rep. 2014;2014:bcr2014205832.

[6] Burke D , Zakhary B , Pinelis E. Acute hemolysis following an overdose of Miracle Mineral Solution in a patient with normal glucose-6-phosphate dehydrogenase levels. Chest. 2014;146(4):273A.

[7] Williams SR , Dawling S , Seger DL. Severe hemolysis in pediatric case after ingestion of Miracle Mineral Solution. Clin Toxicol. 2009;47(7):702–765.


This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 USC. 105, no copyright protection is available for such works under U.S. Law.

To cite this article: Allison Lardieri , Carmen Cheng , S. Christopher Jones & Lynda McCulley (2020): Harmful effects of chlorine dioxide exposure, Clinical Toxicology, DOI: 10.1080/15563650.2020.1818767